Wat is dit voor site? Wij zoeken de goedkoopste boeken op internet. Anti-Cancer N-Heterocyclic Carbene Complexes of Gold(III), Gold(I) and Platinum(II)vonden we het goedkoopst op Bol.com voor €95.99. We hebben gezocht in nieuwe en tweedehands boeken. Rechtsonderaan de pagina kan je het boek direct bestellen via Bol .com.

Anti-Cancer N-Heterocyclic Carbene Complexes of Gold(III), Gold(I) and Platinum(II)

Engels | Druk: 1st ed. 2016 | E-book | 9789811006579

Taotao Zou - 9789811006579

 

Engels | Druk: 1st ed. 2016 | E-book | 9789811006579

This thesis focuses on the development of gold- and non-classical platinum-based anti-cancer agents that display distinctively different anti-cancer mechanisms compared to the commonly used cisplatin. These metal complexes contain N-heterocyclic carbene (NHC) ligands which are able to form strong M-C(NHC) bonds, conferring high stability and favorable lipophilicity, reactivity and binding specificity of metal complexes on biomolecules. The author demonstrates significant advances made in anti-cancer gold(III), gold(I) and platinum(II) complexes. Detailed chemical synthesis, in vitro and/or in vivo anti-cancer activities are clearly presented including: (i) a class of Au(III) complexes containing a highly fluorescent N^N^N ligand and NHC ligand that simultaneously act as fluorescent thiol "switch-on" probes and anti-cancer agents; (ii) a dinuclear gold(I) complex with a mixed diphosphine and bis(NHC) ligand displaying favorable stability and showing significant inhibition of tumor growth in two independent mice models with no observable side effects; and (iii) a panel of stable luminescent cyclometalated platinum(II) complexes exhibiting high specificity to localize to the endoplasmic reticulum (ER) domain, inducing ER stress and cell apoptosis. These works highlight the clinical potential that gold and platinum complexes offer for cancer treatment.

 

 Levertijd:   Direct beschikbaar

95.99

Anti-Cancer N-Heterocyclic Carbene Complexes of Gold(III), Gold(I) and Platinum(II) Engels | Druk: 1st ed. 2016 | E-book | 9789811006579
TaalEngels
BindwijzeE-book
Druk1st ed. 2016
Verschijningsdatumfebruari 2016
Ebook formaatAdobe ePub
IllustratiesNee
AuteurTaotao Zou
UitgeverSpringer
Lees dit ebook opAndroid (smartphone en tablet) | Kobo e-reader | Desktop (Mac en Windows) | iOS (smartphone en tablet) | Windows (smartphone en tablet) | Overige e-reader
Ebook formaatAdobe ePub
Gewicht813 g
StudieboekJa
Verpakking breedte216 mm
Verpakking hoogte11 mm
Verpakking lengte279 mm



Laat hier je e-mail adres achter en de prijs die je voor het boek wil betalen. Wij laten je dan automatisch weten wanneer het boek voor jouw prijs beschikbaar is.



  Bekijk alle opties  Afrekenen  Voeg toe aan lijst